A self-designing rule for clinical trials with arbitrary response variables.
نویسنده
چکیده
For testing both one-sided and two-sided hypotheses concerning several treatment arms in group sequentially performed clinical trials with arbitrary outcome variables, a general method is considered that allows one to completely self-design a study. All information available prior to a stage is used for estimating the sample size and the weight for the next step. In "using up" the variance, the test statistic is built in a bounded finite but random number of stages to test just once the rejection of the null hypothesis. Control Clin Trials 2001;22:111-116
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عنوان ژورنال:
- Controlled clinical trials
دوره 22 2 شماره
صفحات -
تاریخ انتشار 2001